Prostaglandin E2release in gastric antral mucosa of guinea-pigs: basal PGE2release by cyclo-oxygenase 2 and ACh-stimulated PGE2release by cyclo-oxygenase 1
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چکیده
منابع مشابه
Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2.
Prostaglandin (PG) E(1) has been shown to possess anti-inflammatory properties and to modulate vascular reactivity. These activities are sometimes distinct from those of PGE(2), suggesting that endogenously produced PGE(1) may have some beneficial therapeutic effects compared with PGE(2). Increasing the endogenous formation of PGE(1) requires optimization of two separate processes, namely, enri...
متن کاملAsthma relieved by aspirin and by other cyclo-oxygenase inhibitors.
A 62-year-old man had been well until 10 years previously when he experienced a first attack of dry cough. Coughing continued and four years before admission, after a flu-like illness, attacks of breathlessness and wheezing began to occur. Though treated with bronchodilators and prednisone he noticed that asprin relieved his symptoms and began to take it regularly. The frequency and severity of...
متن کاملEvaluation of cytotoxicity mechanism of two cyclo-oxygenase-2 inhibitors in leukemia cell line
Introduction: Leukemia is considered one of the main causes of death, and current chemotherapeutic agents are unable to provide optimal responses due to chemo-resistance. Therefore, there is a constant need for new drugs. Cyclooxygenase- 2 (COX-2) inhibitors can be helpful by reducing the necessary dose of routine chemotherapeutic drugs. Herein, we evaluated the cytotoxicity activity as well...
متن کاملHydroxyl-radical formation during prostaglandin formation catalysed by prostaglandin cyclo-oxygenase [proceedings].
The results indicate that haptoglobin may account for at least part of the inhibitor activity of plasma or serum. This seems to be consistent with the finding that administration of glucocorticoids in rats induced parallel changes in plasma inhibitor activity and haptoglobin concentration. However, no clear relationship between the haptoglobin concentration and the inhibitory actions of several...
متن کاملBiosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa.
The human colon synthetises several prostanoids which may have a role in inflammatory bowel diseases. As lipoxygenase products of arachidonate metabolism have been implicated in inflammatory processes, we have now investigated the formation of both lipoxygenase and cyclo-oxygenase metabolites from [14C]-arachidonic acid [(14C]-AA) by human colonic tissue. Homogenates of human colonic mucosa wer...
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ژورنال
عنوان ژورنال: Experimental Physiology
سال: 2006
ISSN: 0958-0670
DOI: 10.1113/expphysiol.2006.034405